Literature summary extracted from

Walker, F.; Nicole, P.; Jallane, A.; Soosaipillai, A.; Mosbach, V.; Oikonomopoulou, K.; Diamandis, E.P.; Magdolen, V.; Darmoul, D.
Kallikrein-related peptidase 7 (KLK7) is a proliferative factor that is aberrantly expressed in human colon cancer (2014), Biol. Chem., 395, 1075-1086.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.4.21.117	enzyme overexpression in HT-29 cells resulting in increased cell proliferation	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.21.117	extracellular	the enzyme is secreted	Homo sapiens	-	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.117	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.117	colonic adenocarcinoma cell	-	Homo sapiens	-
3.4.21.117	colonic cancer cell	colon cancer cell lines and colonic tumors	Homo sapiens	-
3.4.21.117	additional information	no expression in healthy colon epithelium	Homo sapiens	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.117	kallikrein-related peptidase 7	-	Homo sapiens
3.4.21.117	KLK7	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
3.4.21.117	physiological function	serine proteases of the tissue kallikrein-related peptidases family are implicated in tumorigenesis, kallikrein-related peptidase 7 is a proliferative factor that is aberrantly expressed in human colon cancer and involved in cell proliferation in vitro and in vivo	Homo sapiens

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Release 2023.1 (January 2023)